For nearly two decades, Grizzly 399 has been a fixture in Grand Teton National Park. Known only by her research number, 399 has become the world's most famous — and photographed — grizzly in the world. The film follows 399 as she struggles to raise an unusually large litter in the face of human encroachment, a rapidly changing climate and threat of losing her protection under the Endangered Species Act. Following 399’s decisions and the escalating human conflict, the film raises larger questions about humans’ relationship with nature — and how we connect, control, consume, and conserve it.