World-weary stand-up comedian Kate McLoughlin wants out. Her morbid prayers are answered in the form of a cancer diagnosis. For Kate, this is the perfect excuse. However, a last supper of dodgy shellfish and champagne puts paid to her overdose attempt and to placate her family she begrudgingly agrees to undergo treatment. Armed with staggering levels of cynicism and a plethora of blackly comic jokes, Kate gets off to a bad start with the four other women she encounters on the chemo ward, whose unsolicited friendships are destined to blow open her shut-down heart.