Drive All Night follows Dave, a reclusive swing-shift taxi driver, whose night takes an unexpected turn after he picks up a mysterious passenger, Cara, a young woman hiding a dark secret. She makes him drive around the city without a clear destination or motive, and has him accompany her on a number of bizarre excursions - each one stranger than the next. Unbeknownst to the pair, Lenny, an obsessive hitman, is hunting them, guided by strange visions and instructions from a powerful mob boss.