Buried in a dormant life and a dead end relationship, Dr. Jason Frankenstein--the last of his family--is frustrated to find himself approaching mid-life while having shown little progress towards advancing his family's experiment. But after a creature from his past brutally re-enters his life, he is catalyzed to finally complete his work. With the help of a pair of drug dealing paramedics and a nurse with a shady past, he sets down the blood-soaked path to create a living being from the bodies of the dead.